BMP Bone Grafting (Bone Morphogenetic Protein)
The active ingredient in INFUSE Bone Graft — rhBMP-2 — is a manufactured version of a protein already present in the body that promotes new bone growth.
Certain BMPs have been studied for many years because of their ability to heal bone and eliminate the need for bone graft harvesting from other parts of the body. rhBMP-2 has been studied more than any other BMP and is FDA approved for use in certain spinal, tibial and oral surgeries.
Naturally occurring BMP is found within the bone itself, but only in small amounts. To provide clinically useful and reproducible amounts of isolated, human BMP, it must be manufactured in a special facility.
Scientists isolated the gene for one protein (BMP-2) from bone tissue and used well-established molecular biology techniques to create genetically engineered cells. These cells then produce large quantities of rhBMP-2. The recombinant form of rhBMP-2 is identical to the natural form in both its chemistry and its ability to grow new bone.
During surgery, rhBMP-2 is soaked onto and binds with an absorbable collagen sponge that is designed to resorb, or disappear, over time. As the sponge dissolves, the rhBMP-2 stimulates the cells to produce new bone. The rhBMP-2 also goes away once it has completed its task of initiating the normal bone healing process.
In instances of jaw bone resorption, rhBMP-2 may be placed in the section(s) of the jaw bone that need to be built back up in preparation for dental implants. To learn more about INFUSE Bone Graft, please contact Dr. Shroyer’s office.